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Bioinformatics
Learn about bioinformatics analysis of genomic, transcriptomic, and proteomic data
This course is a part of
During this course, you will gain knowledge of the most essential databases and methods for molecular sequence and structure analysis.
These years, computer based methods play a crucial role in molecular biology, microbiology, and personalised medicine. Huge international databases of sequence and structure contain information, which in many cases can entirely replace experimental work, and in other cases can be used to optimize the benefit of experimental resources.
Introduction to Bioinformatics is a practically oriented course with focus on using the methods rather than deriving them mathematically. Bioinformatics is presented as a biological discipline rooted in evolutionary theory. A large part of the course consists of computer-based exercises, where the computational tools are applied based on the participants’ biological prior knowledge.
Teaching form
- On campus: Lectures and teamwork at DTU campus.
- Online teaching: Online teaching, group work with assignments, and presentations from the students.
- Project work and report writing: The course ends with an interdisciplinary group work based on a case.
Course Directors on Bioinformatics
Carolina Barra Quaglia
Associate Professor
Course details for Bioinformatics
Dates and examination
Place
Technical University of Denmark, Copenhagen
Course dates
Spring 2026. The course dates are yet to be announced.
The course is available every other Spring.
30 seats.
Examination
Please find the exam dates in the exam plan.
You can find relevant information about the exam in the course curriculum.
See an overview of all courses on Master of Personalised Medicine (in Danish).
Learning outcomes
Once you have met the objectives of the course, you will be able to:
- Explain how the information in biological macromolecules, such as DNA and protein can be represented in a digital format.
- Explain how processing of NGS data is done with bioinformatics tools
- Search for sequence data from the publicly available databases, such as GenBank and UniProt, and relevant disease omics data such as the cancer genome atlas (TCGA)
- Use programs to perform basic clustering of patient samples, based on critical feature selection
- Search the clinvar and COSMIC databases of disease related mutations
- Rationally apply bioinformatics tool to answer biological questions relevant to applied personalised medicine
- Explain how patient stratification is done based on genomics, transcriptomics, and proteomics data in practice using basic clustering and classification
Admission criteria
You must meet the following criteria to be admitted to this course:
- Hold a relevant master degree or equivalent
- Have a minimum 2 years of professional experience within personal medicine in a clinical, research or academic field
- Be proficient in English
Find detailed information in the admission criteria on Master of Personalised Medicine (in Danish).
Priority is given to enrolled students
This course is offered as an elective course on the Master of Personalised Medicine programme (website in Danish). Priority is given to students already enrolled on Master of Personalised Medicine. Once the enrolled students have been admitted to the course, the remaining seats are distributed on a first-come, first-served basis.
Tuition fees
EU/EEA citizens: 11.500 DKK
Non-EU/EEA citizens: 15.500 DKK
Terms of Payment (in Danish)
Contact
Janni Stubkjær Rasmussen
Studiekoordinator
Tlf.: +45 35 32 12 79
Place
Technical University of Denmark
Anker Engelunds Vej 101
2800 Kongens Lyngby
Carolina Barra Quaglia
Associate Professor
Carolina Barra Quaglia is the group leader of Protein Immunoinformatics research group at the Health Tech Department of Technical University of Denmark (DTU).
The immune system orchestrates responses in health and disease through a series of events involving antigen processing and presentation, distinguishing between self and foreign entities to ultimately induce immunogenicity. However, in certain situations such as allergy, autoimmunity, or in the treatment with biological protein drugs, the immune system fails to induce tolerance and triggers an undesired immune reaction. The mechanisms behind these responses remain unknown.
The Protein Immunoinformatics group focuses on developing machine learning tools, particularly using protein structural information, deep learning, and computer vision to understand and predict the allergenicity and immunogenicity of the proteins.